Peptide nucleic acid (gold) readily enters DNA's major groove to form triple-stranded and other structures with DNA, allowing it to modify the activity of genes in new ways.Key Concepts
- A synthetic molecule called peptide nucleic acid (PNA) combines the information-storage properties of DNA with the chemical stability of a proteinlike backbone.
- Drugs based on PNA would achieve therapeutic effects by binding to specific base sequences of DNA or RNA, repressing or promoting the corresponding gene.
- Some researchers working to construct artificial life-forms out of mixtures of chemicals are also considering PNA as a useful ingredient for their designs.
- PNA-like molecules may have served as primordial genetic material at the origin of life.
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